Design of mold to yield elastomeric membrane whose shape and size, when inflated, is similar to the shape of the human heart

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Title: Design of mold to yield elastomeric membrane whose shape and size, when inflated, is similar to the shape of the human heart
Author: Lagu, Amit Vinayak
Abstract: Nearly five million Americans are living with heart failure and 550 ,000 new cases are diagnosed each year in the US . Amongst the new approaches to develop a better solution for Congestive Heart Failure , Ventricular Recovery (VR ) holds the most promise . A team , under the guidance of Dr . Criscione in the Cardiac Mechanics Lab at Texas A &M University , is currently developing an investigative device which aims to assist in VR by restoration of physiological strain patterns in the myocardial cells . The contribution of this thesis has been towards the development of a molding apparatus that yields a polymeric membrane whose shape , when inflated , is similar to the shape of the human heart . This membrane would surround the epicardial surface of the heart , when used for the device being discussed and in particular for the prototypes being developed . Contribution also includes a testing apparatus that measures the inflation of a membrane and simulation to predict the behavior of isotropic ellipsoids upon inflation . After unsuccessful implementations of two processing techniques , the successful design , fabrication implementation and attachment method meets the design criteria and is based on a thermoforming technique . Inflation profiles for membranes developed using this technique were studied at different pressures , with the axis length as variable . At 1kpa , which is the normal coronary arterial pressure , the membrane with an axis length of 140mm was found to show a shape which is similar to the shape of the human heart . In order to better understand and predict the shape an isotropic ellipsoidal membrane would take upon inflation without experimentation , simulations were carried out . Successful conversion of ellipsoidal geometry , with a few degrees of freedom as parameters , aided in simulation .
URI: http : / /hdl .handle .net /1969 .1 /1273
Date: 2004-11-15

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Design of mold to yield elastomeric membrane whose shape and size, when inflated, is similar to the shape of the human heart. Available electronically from http : / /hdl .handle .net /1969 .1 /1273 .

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