Nutritional modulation of immunity and physiological responses in beef calves

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Title: Nutritional modulation of immunity and physiological responses in beef calves
Author: Kurz, Michael Wayne
Abstract: Twenty -four crossbred steer calves (235 + 6 kg initial BW ) were weaned , adapted to a growing diet , trained to use Calan feeders and assigned to one of four treatments in a 2 x 2 factorial arrangement as follows : (1 ) no transit stress and saline injection , (2 ) no transit stress and trace mineral and vitamin E (TM /VitE ) injections , (3 ) transit stress and saline injection and (4 ) transit stress and TM /VitE injection . TM /VitE injections consisted of MultiminTM to provide 0 .3 , 0 .6 , 0 .15 and 0 .6 mg of Cu , Mn , Se , and Zn /kg BW , respectively , and Vita ETM to provide 9 IU of VitE /kg BW on d 0 and 21 of the study . On d 24 , transit -stressed steers were subjected to a three -d , 2000 -km , transportation period . During the 56 -d experiment , liver and serum samples were assayed to assess trace mineral status , antibody titers to keyhole limpet hemocyanin (KLH ) measured to assess humoral immunity and phytohemagglutinin (PHA ) - and ovalbumin (OVA ) -induced skin swelling and lymphocyte proliferation measured to assess cellular immunity . TM /VitE -injected steers grew slower (P < 0 .05 ) over the first 24 d of the experiment and tended (P = 0 .10 ) to grow slower after transit . TM /VitE injections increased (P < 0 .05 ) liver Cu and Zn concentrations 135 and 21 % by d 30 , respectively . TM /VitE -injected steers had increased (P < 0 .05 ) serum Cu on d 24 and 26 , but decreased (P < 0 .05 ) serum Zn and whole blood Se compared to saline -injected steers on d 24 and 56 . TM /VitE injections increased serum & #945 ; -tocopherol concentrations . TM /VitE injections did not affect humoral immunity , but decreased (P < 0 .05 ) skin -swelling responses to PHA on d 21 , and decreased (P < 0 .05 ) lymphocyte proliferation to OVA and KLH . Transit -stressed steers had higher (P < 0 .05 ) serum Cu on d 26 , and higher (P < 0 .05 ) liver Cu concentrations on d 56 than non -transit -stressed steers . Transit stress did not affect serum Zn or whole blood Se concentrations . Injections of TM /VitE increased Cu , Zn and vitamin E , but not Se status . The TM /VitE treatment suppressed growth and cellular immune function suggesting that levels of trace minerals used in this study were too high .
URI: http : / /hdl .handle .net /1969 .1 /1096
Date: 2004-11-15

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Nutritional modulation of immunity and physiological responses in beef calves. Available electronically from http : / /hdl .handle .net /1969 .1 /1096 .

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