Ralbp1 In Stress Resistance

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Title: Ralbp1 In Stress Resistance
Author: Drake, Kenneth
Abstract: Ralbp1 is a multi -specific transporter of glutathione conjugates as well as unconjugated amphiphilic toxins . Because glutathione conjugates are major metabolites of toxic lipid peroxidation products generated as a consequence of oxidant and radiant stress , the hypothesis is put forth that the function of Ralbp1 in -vivo and in vitro should be to protect organisms from chemical stress by removing toxic chemicals . Studies described in this dissertation were designed to prove this hypothesis . We tested the hypothesis by examining whether the inhibition or augmentation of Ralbp1 would sensitize or protect cells and whole animals from the toxic effects of chemicals and radiation . These studies establish that Ralbp1 is a primary determinant of resistance to chemical stressors by the direct transport of these toxins .
URI: http : / /hdl .handle .net /10106 /912
Date: 2008-08-08

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Ralbp1 In Stress Resistance. Available electronically from http : / /hdl .handle .net /10106 /912 .

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