|
Abstract:
|
Ralbp1 is a multi -specific transporter of glutathione conjugates as well as unconjugated amphiphilic toxins . Because glutathione conjugates are major metabolites of toxic lipid peroxidation products generated as a consequence of oxidant and radiant stress , the hypothesis is put forth that the function of Ralbp1 in -vivo and in vitro should be to protect organisms from chemical stress by removing toxic chemicals . Studies described in this dissertation were designed to prove this hypothesis . We tested the hypothesis by examining whether the inhibition or augmentation of Ralbp1 would sensitize or protect cells and whole animals from the toxic effects of chemicals and radiation . These studies establish that Ralbp1 is a primary determinant of resistance to chemical stressors by the direct transport of these toxins . |