Computer-aided Patient Specific Treatment Planning Of Cryosurgery For Breast Cancer

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Title: Computer-aided Patient Specific Treatment Planning Of Cryosurgery For Breast Cancer
Author: Jung, Junkyu
Abstract: Cryosurgery , which is to destroy tumors by use of localized freezing , is an emerging treatment modality for breast cancer as the size of detectable tumor becomes smaller due to more frequent use of various diagnostic imaging including MRI , CT and mammogram . Although general surgical guideline has been developed and its effectiveness has been demonstrated , cryosurgical protocol should be adjusted for a given patient to accommodate patient -specific variations including tumor size , location and geometry of patient's breast . In this study , a computerized treatment planning tool was developed to aid surgeons to determine surgical parameters considering patient specific diagnostic information . This tool consists of three modules - 1 ) three dimensional reconstruction of diagnostic images , 2 ) numerical simulation of cryosurgical procedure , and 3 ) prediction of the treatment outcome . Three dimensional image reconstruction was performed by digitizing two patient specific diagnostic images perpendicular to each other , importing the digitized key points of the images into a commercial finite element analysis software (ANSYS ) , and constructing three dimensional volume . With a given surgical parameter , the numerical simulation module performed three dimensional transient thermal analysis of a cryosurgical procedure . Using the results of thermal analysis , the extent of cryodesturction was predicted through an empirical correlation for cryoinjury of human breast cancer cells . By iteratively using the developed modules , the surgical parameters can be determined for optimum treatment outcome .
URI: http : / /hdl .handle .net /10106 /88
Date: 2007-08-23

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Computer-aided Patient Specific Treatment Planning Of Cryosurgery For Breast Cancer. Available electronically from http : / /hdl .handle .net /10106 /88 .

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