Surface Patterning Of Biodegradable Polymer In Tissue Engineering By Applying Photolithography

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Title: Surface Patterning Of Biodegradable Polymer In Tissue Engineering By Applying Photolithography
Author: Su, Lee-Chun
Abstract: The prevalence of cardiovascular disease and inherent problems with current surgical therapies has prompted major efforts in the field of vascular tissue engineering . While there have been significant advances towards creating functional blood vessel substitutes , the fabrication of a vascular graft with mechanical , structural and functional properties similar to native vessels has not yet been achieved . We have presented an observation of a new biodegradable polymer utilized on the research of tissue engineering . Our idea was to create a structure to imitate blood vessel muscles in vitro and also to guide the cells when they start spreading and trying to connect with each other . CUPE is a newly invented biodegradable polymer . It has great mechanical properties and biocompliance . The polymers were imprinted with two shapes of channels from silicon moulds which were fabricated by two different etching methods as cell culture substrates . The result shows that cells were affected by the structure of environment . According to our design of patterns cell growth presented an alignment within the channel grooves . Especially for the one with triangle -shape walls since there is no space for cells to attach and grow on the top area , we can see a clear line which blocks cells from two sides of wall to connect . However , cells will eventually over accrete across the walls and cover the whole polymer surface . This indicates it is crucial to control the amount of cells we use and the time cells grow .
URI: http : / /hdl .handle .net /10106 /757
Date: 2008-04-22

Citation

Surface Patterning Of Biodegradable Polymer In Tissue Engineering By Applying Photolithography. Available electronically from http : / /hdl .handle .net /10106 /757 .

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