New Macrocyclic Glycopeptide Antibiotic For Chiral HPLC Stationary Phases And Ionic Liquids In Analytical Chemistry

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Title: New Macrocyclic Glycopeptide Antibiotic For Chiral HPLC Stationary Phases And Ionic Liquids In Analytical Chemistry
Author: Zhang, Xiaotong
Abstract: The main focus of this dissertation is on the development of new chiral stationary phases for HPLC and GC and the application of ionic liquids in analytical chemistry . They will be discussed separately in two parts . Enantiomeric separations continue to be of great interest to the pharmaceutical industry . It is because drug molecules of opposite chirality often possess distinctive effects in biological environments . Direct chromatography is one of the major techniques used to address the challenge of enantiomeric analysis . Macrocyclic glycopeptides are a very useful class of chiral selectors for HPLC stationary phases because of their broad enantioselectivity . A study of a new macrocyclic glycopeptide antibiotic , dalbavancin , as chiral selector for HPLC will be described in part one . Two stationary phases based on dalbavancin were synthesized via two different binding strategies and compared against with commercial teicoplanin column . The application of Ionic liquids in analytical chemistry is growing rapidly due to their valuable properties such as wide liquid temperature range , high thermal stability , inflammability etc . Several techniques based on ionic liquids are maturing into commercialized products . In part two , the synthesis , physical properties , and the use as ion pairing reagent for anion detection in ESI -MS of linear tricationic ionic liquids will be presented . In chapter 7 , a study of new chiral GC columns using ionic liquids as matrices and methylated ionic cyclodextrin as chiral selector will be discussed .
URI: http : / /hdl .handle .net /10106 /5885
Date: 2011-07-14

Citation

New Macrocyclic Glycopeptide Antibiotic For Chiral HPLC Stationary Phases And Ionic Liquids In Analytical Chemistry. Available electronically from http : / /hdl .handle .net /10106 /5885 .

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