Fabrication And Mechanical Characterization Of A Two-ply Cross Fiber Stent And Fibers Comprising Blends Of Poly(L-lactic Acid)

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dc.contributor Gampa , Sushma en_US
dc.date.accessioned 2007 -08 -23T01 :56 :24Z
dc.date.accessioned 2011 -08 -24T21 :40 :07Z
dc.date.available 2007 -08 -23T01 :56 :24Z
dc.date.available 2011 -08 -24T21 :40 :07Z
dc.date.issued 2007 -08 -23T01 :56 :24Z
dc.date.submitted November 2005 en_US
dc.identifier.uri http : / /hdl .handle .net /10106 /277
dc.description.abstract Recent studies indicate that stabilization of vulnerable atherosclerotic plaques is critical for minimizing acute coronary syndromes . In this regard a new biodegradable stent design , the Two -ply cross fiber stent , has been developed to reduce stent -imposed stresses on such plaque and to provide increased drug reservoir capability . A comparative study of the mechanical properties of Two -ply and Single -ply stent designs was performed . Fibers comprising PLLA blends were developed and their thermal and mechanical properties were determined . Lateral spreading of helical fibers upon deployment of the Two ply design was observed that , in theory , may reduce stresses on the plaque surface . The results indicate that the 1 .5 mm furled Two -ply cross fiber stent can be expanded fully , to 3 .1 ± 0 .1 mm diameter , with an inflation pressure of less than 5 atm . Use of two fiber plies increased the hoop strength without significantly affecting the longitudinal flexibility , thereby maintaining maneuverability whilst improving collapse resistance after deployment . Calorimetry measurements indicate that blends containing up to 50 % of 100kD PLLA are suitable for incorporation of the anti -inflammatory drug Curcumin by melt extrusion . en_US
dc.language.iso EN en_US
dc.publisher Biomedical Engineering en_US
dc.title Fabrication And Mechanical Characterization Of A Two -ply Cross Fiber Stent And Fibers Comprising Blends Of Poly (L -lactic Acid ) en_US
dc.type M .S . en_US

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Fabrication And Mechanical Characterization Of A Two-ply Cross Fiber Stent And Fibers Comprising Blends Of Poly(L-lactic Acid). Available electronically from http : / /hdl .handle .net /10106 /277 .

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