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Abstract:
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Recent studies indicate that stabilization of vulnerable atherosclerotic plaques is critical for minimizing acute coronary syndromes . In this regard a new biodegradable stent design , the Two -ply cross fiber stent , has been developed to reduce stent -imposed stresses on such plaque and to provide increased drug reservoir capability . A comparative study of the mechanical properties of Two -ply and Single -ply stent designs was performed . Fibers comprising PLLA blends were developed and their thermal and mechanical properties were determined . Lateral spreading of helical fibers upon deployment of the Two ply design was observed that , in theory , may reduce stresses on the plaque surface . The results indicate that the 1 .5 mm furled Two -ply cross fiber stent can be expanded fully , to 3 .1 ± 0 .1 mm diameter , with an inflation pressure of less than 5 atm . Use of two fiber plies increased the hoop strength without significantly affecting the longitudinal flexibility , thereby maintaining maneuverability whilst improving collapse resistance after deployment . Calorimetry measurements indicate that blends containing up to 50 % of 100kD PLLA are suitable for incorporation of the anti -inflammatory drug Curcumin by melt extrusion . |