Novel Techniques Of Fabricating Porous, Biodegradable Polymer Scaffolds For Sustained Drug Release

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Title: Novel Techniques Of Fabricating Porous, Biodegradable Polymer Scaffolds For Sustained Drug Release
Author: Uttarwar, Mayur B
Abstract: Two types of porous scaffolds were made from biodegradable polymers and their drug release trends and rates were studied . In first method , the emulsion of PLLA in chloroform solution and PVA and acetaminophen in de -ionized water solution was made . The emulsion was blended with PLLA solution . The resultant emulsion was freeze vacuum dried . The drug release study was conducted in -vitro . In the second method , scaffolds had three layers . The top and bottom layers were made by blending PLLA solution with PVA solution . The middle layer was made by blending PLLA solution with a mixture of PVA and Acetaminophen in de -ionized water solution . The emulsion layers were freeze vacuum dried . The drug release study was conducted over a period of 25 days . Different combinations of PVA concentration and Blender speed were obtained . The cells were cultured and their presence into the scaffolds after 10 days was observed .
URI: http : / /hdl .handle .net /10106 /26
Date: 2007-08-23

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Novel Techniques Of Fabricating Porous, Biodegradable Polymer Scaffolds For Sustained Drug Release. Available electronically from http : / /hdl .handle .net /10106 /26 .

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