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Abstract:
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It is well known that Quillaja saponins have the ability to elicit a strong immune response when used as an adjuvant in an ISCOM matrix . However , to date , the antiviral capability of Quillaja saponins has not been documented . Using extracts from the Chilean Soap Bark Tree (Quillaja Saponaria Molina ) we document the anti -viral capacities of Quillaja saponins against HSV -1 and Vaccinia . The saponin was ineffective against Vaccinia Virus , however neutralized HSV -1 in a time and temperature dependent manner . In addition , Quillaja Saponins were determined capable of preventing cell -to -cell spread when introduced in solution to cell monolayers . |